{"id":328,"date":"2020-10-08T17:43:52","date_gmt":"2020-10-08T17:43:52","guid":{"rendered":"https:\/\/www.joinnbio.com\/?page_id=328"},"modified":"2021-05-25T17:10:31","modified_gmt":"2021-05-25T17:10:31","slug":"formulation-development","status":"publish","type":"page","link":"https:\/\/www.joinnbio.com\/development-services\/formulation-development\/","title":{"rendered":"Formulation Development"},"content":{"rendered":"\n
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<\/div>\n \"Developability\"\n\n<\/div>\n\n\n
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fig. 1 \u2014<\/span><\/div>\n JOINN Biologics <\/span>\n <\/h3>\n\n

\n Formulation Development <\/h2>\n <\/div>\n\n<\/div>\n\n\n
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The Analytics department also design and optimize the formulation of the final product so to achieve sound stability of drug products under various shipping and storage conditions. JOINN Bio\u2019s formulation screen typically includes two steps: <\/p>\n\n\n\n

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Step  1: Screen<\/h2>\n\n\n\n

Screenings are initially done in 96 well format, using turbidity, thermostability and aggregation as read out <\/p>\n\n\n\n

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Thermo Stability by DSF <\/h4>\n<\/div>\n\n\n\n
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Turbidity by plate reader <\/h4>\n<\/div>\n\n\n\n
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Aggregation by light scattering<\/h4>\n<\/div>\n<\/div>\n\n\n\n

Step 2: Confirmation<\/h2>\n\n\n\n

Using viscosity, activity, and aggregation as readout. Samples may need to go through various conditions, such as concentrating (up to 200mg\/ml), multiple freezes and thaws, longer-term storage, or continuous shaking<\/p>\n\n\n\n

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SEC <\/h4>\n<\/div>\n\n\n\n
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Viscosity by Visometer <\/h4>\n<\/div>\n\n\n\n
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MFI with BotI Autosampler <\/h4>\n<\/div>\n\n\n\n
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HIAC Particle Counter<\/h4>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

To learn more, please fill out the form below.<\/h3>\n\n\n\n\n\n
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